First CRISPR Gene Editing Treatment for Sickle Cell Disease
In the history of sickle-cell anaemia, UK and FDA approve gene therapy for the first time! It's a real game [...]
Press release EDITSCD
Institut Imagine (Paris) will coordinate a Horizon Europe-granted project on genome editing approaches to treat sickle cell disease [...]
Paper of the field n°8
Click here to read more about the next-generation in vivo gene editing of human hematopoietic stem and progenitor cells! Abstract for [...]
Kalter, Nechama, et al. "Off-target effects in CRISPR-Cas genome editing for human therapeutics: Progress and challenges". https://doi.org/10.1016/j.omtn.2025.102636
EDITSCD
Cullot, Grégoire, et al. « Genome Editing with the HDR-Enhancing DNA-PKcs Inhibitor AZD7648 Causes Large-Scale Genomic Alterations ». Nature Biotechnology, vol. 43, [...]
EDITSCD
Venkatesan, Vigneshwaran, et al. « Editing the Core Region in HPFH Deletions Alters Fetal and Adult Globin Expression for Treatment of [...]
EDITSCD
September
26th
2025
17:00
EDITSCD & ERN-EuroBloodNet webinar: Basics of gene therapy with lentiviral vectors
ERN-EuroBloodNet and the EDITSCD Consortium is launching the second webinar of the series of webinars regarding gene therapy and genome [...]
Dacquay, Louis C., et al. « Dual Inhibition of DNA-PK and Polϴ Boosts Precision of Diverse Prime Editing Systems ». Nature Communications, [...]
EDITSCD
April
13th
2026
The CRISPR Medecine Conference 2026
The 3rd edition of the CRISPR MEDiCiNE Conference will take place in Copenhagen, Denmark from April 13th - 16th 2026. Marcello Maresca and Ayal Hendel will give [...]
September
22nd
2025
Sickle Cell in Focus Conference 2025
The 18th annual Sickle Cell in Focus conference will be held in a virtual format and will provide a world-class [...]
September
26th
2025
17:00
EDITSCD & ERN-EuroBloodNet webinar: Introduction to SCD and Gene therapy
Stay tuned! ERN-EuroBloodNet and the EDITSCD Consortium are launching a series of webinars aimed at providing an overview of gene [...]
EDITSCD & ERN-EuroBloodNet: Focus on Genetic Therapy for People Living with SCD
ERN-EuroBloodNet and the EDITSCD Consortium are launching a series of webinars aimed at providing an overview of gene therapy and [...]
EDITSCD
Sobrino, Steicy, et al. « Severe Inflammation and Lineage Skewing Are Associated with Poor Engraftment of Engineered Hematopoietic Stem Cells in [...]
EDITSCD
Paper of the field n°7
Click here to read more about the new method that speeds up gene editing by using packaged CRISPR–Cas9 tools.! Abstract for [...]
June
12th
2025
EHA Research Conference 2025
The European Hematology Association (EHA) will host the EHA 2025 Congress in Milan from June 12 to 15, 2025. The scientific [...]
Brusson, Megane, et Annarita Miccio. « Une approche CRISPR/Cas pour traiter les β-hémoglobinopathies ». médecine/sciences, vol. 41, no 1, janvier 2025, p. [...]
EDITSCD
Frati, Giacomo, et al. « Safety and Efficacy Studies of CRISPR-Cas9 Treatment of Sickle Cell Disease Highlights Disease-Specific Responses ». Molecular Therapy: [...]
EDITSCD
Paper of the field n°6
Click here to read more about the genome engineering with Cas9 and adeno-associated virus strategies! Abstract for General public Genome editing using [...]
September
15th
2025
Annual meeting 2025 in-person
After three years of project, the Consortium met in person on September 15th and 16th, 2025 to debrief. A summary [...]
November
27th
2025
09:00
Scientific meeting – November 2025
A Scientific meeting has been held on November 27th, 2025 on Teams with all Consortium members to present ongoing experiments and updated [...]
May
30th
2025
09:00
Scientific meeting – May 2025
A Scientific meeting has been held on May 30th, 2025 on Teams with all Consortium members to present ongoing experiments and updated [...]
March
19th
2025
09:00
Scientific meeting – March 2025
A Scientific meeting was held on March 19th, 2025 on Teams with all Consortium members to present ongoing experiments and updated EDITSCD results.
November
4th
2024
ADVANCING CRISPR-BASED THERAPIES: A Seminar on sgRNA Synthesis
Members of EDITSCD Consortium will join the Synthego Seminar in Paris to discuss sgRNA manufacturing, CRISPR nucleases for therapeutic development [...]
October
22nd
2024
World Orphan Drug 2024
Congress Europe 2024 The World Orphan Drug Congress is the largest and most established orphan drugs & rare diseases meeting of its [...]
November
21st
2024
6th ERN-EuroBloodNet Progress Meeting
The ERN-EuroBloodNet Progress Meetings, are organized every autumn by the ERN-EuroBloodNet Coordination team, to promote networking among the haematologic stakeholders with the aim of identifying needs [...]
